The activation of galanin receptor 2 plays an antinociceptive effect in nucleus accumbens of rats with neuropathic pain

Abstract Our previous research has shown that galanin plays an antinociceptive effect via binding to receptors (GalRs) in nucleus accumbens (NAc). This study focused on the involvement of GalR2 galanin-induced NAc neuropathic pain rats. The chronic constriction injury sciatic nerve (CCI) was used mimic model. hind paw withdrawal latency (HWL) thermal stimulation and threshold (HWT) mechanical were measured as indicators threshold. results showed 14 28 days after CCI, expression up-regulated bilateral rats, intra-NAc injection antagonist M871 reversed increases HWL HWT CCI Furthermore, agonist M1145 induced at day which could also be by M871. Finally, we found M1145-induced rats stronger than intact These imply is activated from involved